Silicone implants and autoimmune conditions (ASIA syndrome)

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Special Issue ASIA – Autoimmune Syndrome Induced by Adjuvants

From Lupus

In 1976 researchers in Japan reported on 9 cases of systemic sclerosis in subjects with silicone implants. A further 100 similar cases were quickly then discovered followed by  hundreds of case reports and patient studies reporting the development of diverse clinical symptoms following the insertion of silicone implants, which especially when these implants had ruptured. However, even when not ruptured an increased incidence of autoantibodies was recorded in many of these subjects. We now know that an asymptomatic presence of autoantibodies in the serum may precede the eventual development of full blown autoimmune diseases by several years. This new syndrome has been called ASIA (Autoimmune syndrome induced by adjuvant). Silicone was selected for use within implants because of its consistency as well as the belief that it is inert and would not be targeted by the immune system, yet it has been found to act as an adjuvant, especially when invading neighboring tissues when an implant ruptures. The recent use of cheaper implants by the French company PIP has highlighted the increased rate of early rupture in such products and raised the importance of investigations into the development of ASIA. This special issue of Lupus (February 2012) details many clinical conditions which form the ASIA syndrome.

Read the editorial for free
Agmon-Levin, N., Hughes, G., & Shoenfeld, Y. (2012). The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’ Lupus, 21 (2), 118-120 DOI: 10.1177/0961203311429316

Link to table of contents of special issue (February 2012 Volume 21 Issue 2)

Contents include

  • Foreword
  • Editorial – The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’
  • Clinical manifestation of ASIA
  • Silicone and scleroderma revisited
  • Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld’s syndrome)
  • Autoimmune Syndrome Induced by Adjuvants (ASIA) in the Middle East: morphea following silicone implantation
  • Still’s disease, lupus-like syndrome, and silicone breast implants. A case of ‘ASIA’ (Shoenfeld’s syndrome)
  • Autoimmunity following Hepatitis B vaccine as part of the spectrum of ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’ (ASIA): analysis of 93 cases
  • Giant cell arteritis and polymyalgia rheumatica after influenza vaccination: report of 10 cases and review of the literature
  • Systemic lupus erythematosus following HPV immunization or infection?
  • Influenza vaccination can induce new-onset anticardiolipins but not β2-glycoprotein-I antibodies among patients with systemic lupus erythematosus
  • Autoimmune response following influenza vaccination in patients with autoimmune inflammatory rheumatic disease
  • Macrophagic myofasciitis: characterization and pathophysiology
  • Gulf War Syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA)
  • Experimental models of ASIA
  • Vaccine model of antiphospholipid syndrome induced by tetanus vaccine
  • Induction of the ‘ASIA’ syndrome in NZB/NZWF1 mice after injection of complete Freund’s adjuvant (CFA)
  • Adjuvant immunization induces high levels of pathogenic antiphospholipid antibodies in genetically prone mice: another facet of the ASIA syndrome
  • Adjuvants – Biology, mechanisms and related diseases
  • Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
  • Aluminum as an adjuvant in Crohn’s disease induction

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