Posts Tagged ‘antidepressant’

The unsuccessful antidepressant drug discovery process indicates a catastrophic systems failure

December 24, 2012

The failure of the antidepressant drug discovery process is systemic

From Journal of Psychopharmacology

Depression is widespread and accounts for approximately 12% of the total burden of non-fatal global disease. In the developed world around 25% of people can expect to experience this at some point in their lives. First line treatments for depression are mostly drugs based with antidepressants being the third most commonly prescribed medication in the United States. There are strong clinical and commercial pressures for new antidepressant drugs. However the prospects for this are reduced as several major pharmaceutical companies have abandoned research work whilst many others have decreased their research investment. It is argued these trends are indicative of a catastrophic systems failure. The aim of this paper is to explore the reasons why this hiatus has occurred and ways in which this knowledge can be used to help inform efforts to get the antidepressant drug discovery process moving forward once again.


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